Membrane with immobilized anticoagulant and process for producing same
OwnerMatthias WESSLING, Michael ALDERS +7inventors
InventorsMatthias WESSLING, Michael ALDERS, Ilka ROSE, Michael KATHER, Ralf MENDA, Bernd KRAUSE, Markus STORR, Martin REMPFER, Vivian Stefan KURBEL
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Abstract
The present disclosure relates to an anticoagulant-coated microporous hollow fiber membrane showing reduced thrombogenicity. The disclosure further relates to a method for producing the membrane and a filtration and/or diffusion device comprising the membrane.
Claims21
A porous hollow fiber membrane having an anticoagulant immobilized thereon;
- the membrane comprising a blend of i) a polysulfone, polyethersulfone or polyarylethersulfone;
- ii) a polyvinylpyrrolidone;
- and iii) a chitosan.
A process for preparing a porous hollow fiber membrane having an anticoagulant immobilized thereon, comprising the production of a microporous hollow fiber support membrane and subsequent grafting of an anticoagulant onto at least one surface of the support membrane, wherein the production of the microporous hollow fiber support membrane comprises the steps of
- a) forming a polymer solution comprising at least one polysulfone, polyethersulfone or polyarylethersulfone;
- at least one polyvinylpyrrolidone;
- at least one chitosan;
- and N-methyl-2-pyrrolidone;
- b) extruding the polymer solution through an outer ring slit of a nozzle with two concentric openings into a precipitation bath;
- simultaneously
- c) extruding a center fluid through the inner opening of the nozzle;
- d) washing the membrane obtained;
- subsequently
- e) drying the membrane;
- wherein the polymer solution comprises from 10 to 15 wt. %, relative to the total weight of the polymer solution, of polysulfone, polyethersulfone or polyarylethersulfone;
- and from 1 to 10 wt. %, relative to the total weight of the polymer solution, of polyvinylpyrrolidone;
- and from 0.05 to 0.6 wt. %, relative to the total weight of the solution, of chitosan.
(canceled)
Dependencies are inferred from the claim text.