Conjugates of tumor necrosis factor inhibitors to functionalized polymers

A preparation comprising a compound of formula (2):

• or a salt thereof, wherein:
• polymer is a linear, water-soluble, non-peptidic, and non-nucleotidic polymer backbone, wherein each linking group is bonded at a different terminus of said polymer;
• E and E1 are independently O or S;
• K and K1 are independently selected from the group consisting of:
• alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene;
• G and G1 are independently absent or are selected from the group consisting of:
• alkoxy and a hydrophobic separation handle;
• each pair of Z1 and Z2 and Z3 and Z4 are independently selected from O and NH, wherein only one of each pair of Z1 and Z2 and Z3 and Z4 can be NH;
• L and L1 are independently selected from the group consisting of:
• a divalent radical of a nucleoside, alkylene, alkyleneoxyalkylene, oligomeric alkyleneoxyalkylene, and unsubstituted and substituted arylene;
• M and M1 are independently selected from a protected group that when deprotected is reactive with a TNF inhibitor or said derivative or a group reactive with a TNF inhibitor or said derivative, wherein M and M1 are different;
• and
• R and R1 are independently absent, hydrogen, a protecting group, or an activating group;
• wherein when M is a protected group that when deprotected is reactive with a TNF inhibitor or said derivative, then R is a protecting group or a hydrophobic separation handle;
• wherein when M is a group reactive with a TNF inhibitor or said derivative, R is absent, hydrogen, or an activating group;
• wherein when M1 is a protected group that when deprotected is reactive with a TNF inhibitor or said derivative, then R1 is a protecting group or a hydrophobic separation handle;
• and
• wherein when M1 is a group reactive with a TNF inhibitor or said derivative, R1 is absent, hydrogen, or an activating group.