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US 2024/0067958 A1Published application
Engineered enveloped vectors and methods of use thereof
AssigneeGigaMune, Inc.
InventorsDavid Scott JOHNSON, Matthew James SPINDLER, Robert EDGAR, Yoong Wearn LIM, Taylor WELLER
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Abstract
The present disclosure relates to a novel, engineered enveloped vector that can be used for gene delivery. The engineered enveloped vector comprises an engineered envelope comprising: (a) a viral envelope protein and optionally, (b) a non-viral membrane-bound protein. The present disclosure also provides a method of making and using the engineered enveloped vector.
Claims20
An engineered enveloped vector comprising an engineered envelope, wherein the engineered envelope comprises:
- (a) a viral envelope protein having at least 90%, 95%, 96%, 97%, or 99% sequence identity to a sequence selected from SEQ ID NOs:
- 1-167 or SEQ ID NOs:
- 8154-16497;
- and
- (b) optionally, a non-viral membrane-bound protein comprising:
- (i) an optional signal peptide (S);
- (ii) an extracellular targeting domain (ETD);
- and
- (iii) a membrane-bound domain (MBD).
6 more elements
20-30. (canceled)
Dependencies are inferred from the claim text.