Iodotyrosine derivatives and process for preparing iodotyrosine derivatives

A compound of general formula I

• wherein
• A is selected from the group consisting of an unbranched or branched alkyl group with 1 to 12 carbon atoms, an —R1—O—R2 group, an —R1—Si(R3R4R5) group, an —R1—O—Si(R3R4R5) group, a —C(O)—O—R9—Si(R3R4R5) group, a —CH(O—R6)(O—R7) group, an —R1—CH(O—R6)(O—R7) group, an —R1—O—C(O)—O—R8 group;
• SG is a protective group;
• R1 is a divalent hydrocarbon residue with 1 to 12 carbon atoms;
• R2 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• R3, R4 and R5 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• R6 and R7 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• R8 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• and
• R9 is a divalent hydrocarbon residue with 1 to 12 carbon atoms.

A method for the preparation of the compound according to claiml6, comprising reacting a compound of general formula II

• wherein SG is a protective group,
• with a compound of general formula X-A, wherein
• X is halogen or ammonium and
• A is selected from the group consisting of an unbranched or branched alkyl group with 1 to 12 carbon atoms, an —R1—O—R2 group, an —R1—Si(R3R4R5) group, an —R1—O—Si(R3R4R5) group, a —C(O)—O—R9—Si(R3R4R5) group, a —CH(O—R6)(O—R7) group, an —R1—CH(O—R6)(O—R7) group, an —R1—O—C(O)—O—R8 group;
• R1 is a divalent hydrocarbon residue with 1 to 12 carbon atoms;
• R2 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• R3, R4 and R5 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• R6 and R7 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• R8 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms;
• and
• R9 is a divalent hydrocarbon residue with 1 to 12 carbon atoms,
• to form a compound of general formula I
• wherein A and SG have the meanings given in connection with formula II.