Method, system and/or apparatus for use of liquid or fluid carbon dioxide in extraction and/or solubilising source material and binding and/or elution with a molecularly imprinted polymer
AssigneeLigar Limited Partnership
InventorsAaron Wai Kit Low, Bryce William Jamieson
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Abstract
This disclosure relates to a method/system for associating at least one target molecule with a molecularly imprinted polymer and/or a method/system of obtaining at least one target molecule from a source material. More particularly, this disclosure relates to use of liquid or fluid carbon dioxide in various steps related to use of molecularly imprinted polymers.
Claims37
A method of obtaining at least one target molecule from a source material, the method comprising:
- a) bringing a source material into contact with a molecularly imprinted polymer (MIP) to associate at least one target molecule present in the source material with the molecularly imprinted polymer,
- b) eluting the at least one target molecule off the MIP using liquid or fluid carbon dioxide as an elution solvent,
- wherein the liquid or fluid carbon dioxide used as an elution solvent is a pressure of above about 7 MPa and a temperature of above about 31° C., or
- wherein the liquid or fluid carbon dioxide used as an elution solvent is a pressure of about 0.5 to 41 MPa and a temperature of about −50 to 30° C.
The method of claim 20 or 21 wherein the source material is solubilised in supercritical carbon dioxide.
A method for associating at least one target molecule with a molecularly imprinted polymer, the method comprising:
- i) solubilising a source material in liquid or fluid carbon dioxide and
- ii) bringing the solubilised source material in the liquid or fluid carbon dioxide into contact with a molecularly imprinted polymer (MIP) to associate at least one target molecule present in the source material with the molecularly imprinted polymer,
- wherein the liquid or fluid carbon dioxide is at a first pressure and temperature combination when solubilising the source material and at a second pressure and temperature combination when bringing the solubilised source material into contact with the molecularly imprinted polymer (MIP).
A system for obtaining at least one target molecule from a source material, the system comprising:
- a molecularly imprinted polymer,
- a device for providing a flow of liquid or fluid carbon dioxide,
- wherein the system is adapted to bring a source material into contact with a molecularly imprinted polymer to associate at least one target molecule present in the source material with the molecularly imprinted polymer, and
- wherein the system is adapted to elute the target molecule that is associated with the molecularly imprinted polymer using the flow of liquid or fluid carbon dioxide as an elution solvent, and wherein the carbon dioxide is at a pressure of above about 7 MPa and temperature of above about 31° C., or
- wherein the system is adapted to elute the target molecule that is associated with the molecularly imprinted polymer using the flow of liquid or fluid carbon dioxide as an elution solvent, and wherein the carbon dioxide is at a pressure of about 0.5 to 41 MPa and a temperature of about −50 to 30° C.
A system for associating at least one target molecule with a molecularly imprinted polymer, the system comprising:
- a molecularly imprinted polymer,
- at least one device for providing a flow of liquid or fluid carbon dioxide at a first pressure and temperature combination and a second pressure and temperature combination,
- wherein the system is adapted to solubilise a source material in the liquid or fluid carbon dioxide, and
- wherein the system is adapted to bring the solubilised source material into contact with a molecularly imprinted polymer to associate at least one target molecule present in the source material with the molecularly imprinted polymer,
- wherein the liquid or fluid carbon dioxide is at the first pressure and temperature combination when solubilising the source material and at the second pressure and temperature combination when bringing the solubilised source material into contact with the molecularly imprinted polymer (MIP).
Dependencies are inferred from the claim text.