Methods, compounds, and compositions for modifying car-t cell activity
OwnerPhilip S. LOW, John Victor NAPOLEON +1inventors
InventorsPhilip S. LOW, John Victor NAPOLEON, Qian LUO
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Abstract
Compounds, compositions and methods for reducing off-target toxicity of T cells expressing a chimeric antigen receptor (CAR-T cells) and/or providing enhanced control of CAR-T cell activation, and methods of treating a subject and/or modifying CAR-T cell activity in a subject with cancer.
Claims37
1-51. (canceled)
A combination for modifying T cell activity in a subject with cancer, wherein the combination comprises:
- one or more adaptor compounds, or pharmaceutically acceptable salts thereof, wherein each adaptor compound, or pharmaceutically acceptable salt thereof, comprises a small molecule ligand linked to a first targeting moiety;
- and
- an activity modify compound linked to a second targeting moiety, the activity modify compound comprising:
- a rejuvenating compound, or a pharmaceutically acceptable salt thereof, or
- an immunosuppressive compound, or a pharmaceutically acceptable salt thereof.
53-55. (canceled)
(canceled)
64-65. (canceled)
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82-87. (canceled)
A method of treating a subject having received CAR-T cell therapy comprising:
- administering to the subject one or more adaptor compounds, or pharmaceutically acceptable salts thereof, each adaptor compound or pharmaceutically acceptable salt thereof comprising a small molecule ligand linked to a first targeting moiety, wherein, prior to administering the one or more adaptor compounds or pharmaceutically acceptable salts thereof to the subject, the subject has received at least a dose of T cells expressing a chimeric antigen receptor (CAR) that recognizes and binds to the first targeting moiety;
- and
- administering to the subject an activity modifying compound linked to a second targeting moiety, wherein the CAR recognizes and binds to the second targeting moiety.
Dependencies are inferred from the claim text.