Antithrombin heparan sulfate for detection and treatment of cancer
AssigneeThe Regents of the University of California
InventorsRyan Weiss, Thomas Mandel Clausen, Jeffrey D. Esko
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Abstract
Methods of detecting and treating an epithelial carcinoma, such as pancreatic ductal adenocarcinoma cancer or bladder cancer, expressing antithrombin-binding heparan sulfate (HSAT) in a subject, comprising combining a biological sample of the subject containing HSAT with antithrombin and detecting binding of HSAT and the antithrombin, optionally determining that the antithrombin inhibits factor Xa.
Claims20
A method of detecting antithrombin-binding heparan sulfate (HSAT) in a biological sample comprising combining the biological sample with antithrombin and detecting binding of HSAT and the antithrombin, thereby detecting HSAT in the sample.
A method of detecting a cancer expressing antithrombin-binding heparan sulfate (HSAT) in a subject comprising combining a biological sample of the subject with antithrombin, and detecting binding of HSAT and the antithrombin, thereby detecting the cancer in the subject.
A method of treating a cancer expressing antithrombin-binding heparan sulfate (HSAT) in a subject comprising combining a biological sample of the subject containing HSAT with antithrombin, detecting binding of HSAT and the antithrombin, and treating the subject for the cancer by administering an effective amount of cancer therapy.
A method of producing antithrombin-binding heparan sulfate (HSAT), comprising culturing mammalian bladder cancer cells and purifying HSAT from the cultured cells.
Dependencies are inferred from the claim text.