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US 2024/0052013 A1Published application
Systems and methods to link cd40 signaling to antigen binding
AssigneesFred Hutchinson Cancer Center, University of Washington
InventorsJustin J. Taylor, Laila Shehata, Marti Tooley
Life of this patent
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Abstract
Systems and methods to link CD40 signaling to antigen binding, independently of CD40 ligand binding are described. The systems and methods include fusion proteins including an extracellular antigen binding domain linked to an intracellular CD40 signaling domain.
Claims71
A fusion protein, the expression of which in a B cell, results in CD40 activation independently of CD40 ligand (CD40L) binding.
Dependencies are inferred from the claim text.