Novel nampt enzyme agonist and preparation and use thereof

An aromatic compound having structural formula shown in formula I or formula

• where, X represents 0 or NH;
• Y represents O;
• n is 0 or 1;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 each independently represent H, C1-C6 straight or branched chain alkyl, C3-C6 cycloalkyl, halogen substituted C1-C6 straight or branched chain alkyl, hydroxyl, mercapto, halogen, cyano, nitro, boronic acid group, boron ester group, carboxyl, ester, carbonyl, phenoxy, amidino, amido, imide, sulfanilamide, pyrazolyl, substituted or unsubstituted amino, substituted or unsubstituted morpholinyl, substituted or unsubstituted piperidyl, substituted or unsubstituted piperazinyl, substituted or unsubstituted phenyl, substituted or unsubstituted pyridyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C1-C4 alkyl hydroxyl, substituted or unsubstituted C1-C4 alkyl morpholinyl, substituted or unsubstituted C1-C4 alkyl piperidinyl, substituted or unsubstituted C1-C4 alkyl piperazinyl;
• the substituted morpholinyl means that one or more carbons on the morpholinyl are substituted by the following groups:
• hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, halogen, halogen substituted C1-C6 alkyl (such as trifluoromethyl), nitro, cyano, amino or substituted amino;
• the substituted piperidinyl means that one or more carbons on the piperidinyl are substituted by the following groups:
• hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, halogen, halogen substituted C1-C6 alkyl (such as trifluoromethyl), nitro, cyano, amino or substituted amino;
• the substituted piperazinyl means that one or more carbons on the piperazinyl are substituted by the following groups:
• hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, halogen, halogen substituted C1-C6 alkyl (such as trifluoromethyl), nitro, cyano, amino or substituted amino, and can also be that the H on the N of piperazinyl is substituted by the following groups:
• unsubstituted C1-C6 alkyl or substituted C1-C6 alkyl, unsubstituted C1-C6 alkoxy or substituted C1-C6 alkoxy, acyl;
• the substituted C1-C6 alkyl means that one or more hydrogens on the unsubstituted C1-C6 alkyl are substituted by hydroxyl, halogen, nitro, cyano, amino, unsubstituted phenyl or substituted phenyl;
• the unsubstituted C1-C4 alkoxy is selected from a group consisting of methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, or tert-butoxy;
• the substituted C1-C4 alkoxy means that one or more hydrogens on the unsubstituted C1-C4 alkoxy are substituted by hydroxyl, halogen, nitro, cyano, amino, phenyl or substituted phenyl, and can also mean that one or more carbons on the unsubstituted C1-C4 alkoxy are substituted by O, N;
• the substituted phenyl means that one or more hydrogens on the benzene ring are substituted by the following groups:
• hydroxyl, unsubstituted C1-C4 alkyl or substituted C1-C4 alkyl, unsubstituted C1-C4 alkoxy or substituted C1-C4 alkoxy, halogen, nitro, cyano, amino;
• the unsubstituted pyridyl means that the connection position is on different carbons of the pyridyl, such as 2-pyridyl, 3-pyridyl, 4-pyridyl;
• the substituted pyridyl means that one or more carbons on the pyridyl are substituted by the following groups:
• hydroxyl, C1-C4 alkyl, C1-C4 alkoxy, halogen, halogen substituted 1C-6C alkyl (such as trifluoromethyl), nitro, cyano, amino or substituted amino;
• the unsubstituted C1-C4 alkylamino is selected from a group consisting of methylamino, ethylamino, n-propylamino, isopropylamino, formylamino, acetamido, formimidoamino, cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino;
• the substituted C1-C4 alkylamino means that one or more hydrogens on the alkyl of unsubstituted C1-C4 alkylamino are substituted by hydroxyl, halogen, cyano, amino, phenyl or substituted phenyl, and can also mean that one or more carbons on the alkyl of unsubstituted C1-C4 alkylamino are substituted by N, and can also mean that one or more H on N of the unsubstituted C1-C4 alkylamino is substituted by methyl, ethyl, formyl, acetyl, cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino;
• the unsubstituted C1-C4 alkyl hydroxyl means methyl hydroxyl, ethyl hydroxyl, n-propyl hydroxyl, isopropyl hydroxyl, n-butyl hydroxyl, isobutyl hydroxyl, tert-butyl hydroxyl;
• the substituted C1-C4 alkyl hydroxyl means that one or more hydrogens on the alkyl of unsubstituted C1-C4 alkyl hydroxyl are substituted by hydroxyl, halogen, cyano, amino, phenyl or substituted phenyl, and can also means that one or more carbons on the alkyl of the unsubstituted C1-C4 alkyl hydroxyl are replaced by O, N;
• the unsubstituted C1-C4 alkyl morpholinyl means that methyl morpholinyl, ethyl morpholinyl, n-propyl morpholinyl, isopropyl morpholinyl, n-butyl morpholinyl, isobutyl morpholinyl, tert-butyl morpholinyl;
• the substituted C1-C4 alkyl morpholinyl means that one or more hydrogens on the alkyl of the unsubstituted C1-C4 alkyl morpholinyl are substituted by hydroxyl, halogen, cyano, amino, phenyl or substituted phenyl, and can also mean that one or more carbons on the alkyl of unsubstituted C1-C4 alkyl morpholinyl are substituted by O, N;
• the unsubstituted C1-C4 alkyl piperidinyl means that methyl piperidinyl, ethyl piperidinyl, n-propyl piperidinyl, isopropyl piperidinyl, n-butyl piperidinyl, isobutyl piperidinyl, tert-butyl piperidinyl;
• the substituted C1-C4 alkyl piperidinyl means that one or more hydrogens on the alkyl of unsubstituted C1-C4 alkyl piperidinyl are substituted by hydroxyl, halogen, cyano, amino, phenyl or substituted phenyl;
• the unsubstituted C1-C4 alkyl piperazinyl means that methyl piperazinyl, ethyl piperazinyl, n-propyl piperazinyl, isopropyl piperazinyl, n-butyl piperazinyl, isobutyl piperazinyl, tert-butyl piperazinyl;
• the substituted C1-C4 alkyl piperazinyl means that one or more hydrogens on the alkyl of unsubstituted C1-C4 alkyl piperazinyl are replaced by hydroxyl, halogen, cyano, amino, phenyl or substituted phenyl, and can also mean that the H on the N of unsubstituted C1-C4 alkyl piperazinyl are substituted by the following groups:
• unsubstituted C1-C4 alkyl or substituted C1-C4 alkyl, unsubstituted C1-C4 alkoxy or substituted C1-C4 alkoxy, acyl;
• the substituted amino is selected from a group consisting of methylamino, dimethylamino, ethylamino, diethylamino, n-propylamino, di-n-propylamino, isopropylamino, diisopropylamino, formylamino, acetylamino, formimidoamino, cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino, and can also mean that azacyclobutyl, azacyclopentyl, azacyclohexyl, 2-oxo-azacyclobutyl, 2-oxo-azacyclopentyl, 2-oxo-azacyclohexyl;
• the benzene ring in formula I or formula II can also be substituted by other aromatic rings;
• wherein, the substituted amino means that at least one H on the amino is substituted by C1-C6 alkyl or tert-butyloxycarboryl;
• the other aromatic rings are pyridine rings, naphthalene rings, furan rings, pyrrole rings or quinoline rings;
• or a pharmaceutically acceptable salt thereof.