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US 2024/0043532 A1Published application
Nkg2a-targeting antibody and use thereof
AssigneeBioheng Therapeutics Limited
InventorsYali ZHOU, Gong CHEN, Xiaoyan JIANG, Tingting GUO, Jiangtao REN, Xiaohong HE, Yanbin WANG, Lu HAN
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Abstract
Provided are an NKG2A-targeting antibody, and a multispecific antibody, a chimeric receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with NKG2A expression.
Claims24
A NKG2A-targeting antibody, comprising a light chain variable region and a heavy chain variable region, wherein the light chain variable region comprises CDR-L1 as set forth in SEQ ID NO:
- 1, CDR-L2 as set forth in SEQ ID NO:
- 2, and CDR-L3 as set forth in SEQ ID NO:
- 3, and the heavy chain variable region comprises CDR-H1 as set forth in SEQ ID NO:
- 4, CDR-H2 as set forth in SEQ ID NO:
- 5, and CDR-H3 as set forth in SEQ ID NO:
- 6, wherein the light chain variable region comprises amino acid M at position 21, and amino acid T at position 85, and the heavy chain variable region comprises amino acid M at position 34, amino acid A at position 49, amino acid P at position 61, and amino acid T at position 97.
3 more elements
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Dependencies are inferred from the claim text.