Heparinized small-diameter vascular grafts
AssigneeThe Johns Hopkins University
InventorsSharon Gerecht, Morgan B. Elliott, Hai-Quan Mao, Theresa Chen, Khyati Prasad
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Abstract
Described are methods for embedding one or more therapeutic agents into vascular grafts and other scaffold-based devices, and methods of implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds comprise hydrogel nanofibers that have internally aligned polymer chains and may contain one or more therapeutic agents.
Claims39
A method for preparing a vascular graft, the method comprising:
- (a) conjugating one or more therapeutic agents to a protein to form a therapeutic agent-protein conjugate;
- (b) electrospinning a mixture of the therapeutic agent-protein conjugate and the protein to form a plurality of microfibers having the one or more therapeutic agents embedded therein;
- (c) forming one or more sheets comprising the plurality of microfibers having the one or more therapeutic agents embedded therein;
- and
- (d) forming a hollow tube comprising the one or more sheets of the plurality of microfibers having the one or more therapeutic agents embedded therein.
A vascular graft comprising one or more sheets or hollow tubes comprising a plurality of microfibers having one or more therapeutic agents embedded therein.
A kit comprising a powdered LMWH-fibrinogen conjugate, or reagents for preparing the powdered LMWH-fibrinogen conjugate and solutions for reconstituting the powdered LMWH-fibrinogen conjugate for use in electrospinning.
Dependencies are inferred from the claim text.