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US 2024/0035014 A1Published application
Tunable nanoscale cages from self-assembling dna and protein building blocks
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsNicholas Stephanopoulos, Yang Xu
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Abstract
Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.
Claims8
A polyhedral nanocage comprising:
- a multimeric protein, wherein each monomer of the multimeric protein is covalently linked to a polynucleotide handle;
- and
- a DNA assembly of at least 4 oligonucleotides comprising a polynucleotide arm complementary to the polynucleotide handle, wherein the polynucleotide handle and the polynucleotide arm are hybridized to form a double stranded DNA helix linking the multimeric protein to the DNA assembly.
Dependencies are inferred from the claim text.