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US 2024/0034741 A1Published application
Methods for crystallization of drugs
AssigneeBoston Scientific Scimed, Inc.
InventorsHONGXIA ZENG, JONATHAN PASCAL CHAKY, YEN-LANE CHEN
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Abstract
Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.
Claims20
A method for crystallizing a drug, the method comprising:
- forming a solvent solution;
- forming a surfactant solution by adding a first portion of the solvent solution to a surfactant;
- forming a nucleation initiator solution by adding a second portion of the solvent solution to a quantity of drug microcrystals;
- mixing the nucleation initiator solution with a quantity of amorphous drug particles to form a drug mixture;
- and
- adding the surfactant solution to the drug mixture.
3 more elements
A method for crystallizing a drug, the method comprising:
- combining (a) a nucleation initiator mixed with a solvent and (b) an amorphous form of a drug with a surfactant to form a drug precursor dispersion/suspension;
- and
- incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.
A method for crystallizing a drug, the method comprising:
- combining (a) a nucleation initiator mixed with a solvent and (b) an amorphous form of a drug to form a drug precursor dispersion/suspension;
- adding a surfactant solution to the drug precursor dispersion/suspension;
- and
- incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.
1 more element
Dependencies are inferred from the claim text.