A Flexible Osteochondral or Chondral Graft
OwnerSuzanne TABBAA, Farshid GUILAK +1inventors
InventorsSuzanne TABBAA, Farshid GUILAK, William BUGBEE
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Abstract
A flexible osteochondral tissue graft or graft containing cartilage and underlying bone is provided with slits formed by water cutting. Various slit designs, or grooves enhance the flexibility of the graft and create a controlled open-pore structure to enhance cell infiltration and/or tissue integration.
Claims19
A flexible osteochondral graft for implantation into a implantation site having a implantation site radius of curvature said graft comprising:
- a cartilage layer and
- a boney region attached to the cartilage layer and having an outer surface wherein the graft has a harvested state with a first radius of curvature and an implantation state wherein an outer surface of the boney region is provided with a plurality of linear cuts that serve to decrease the radius of curvature of the outer surface from the first radius of curvature in the harvested state to a second radius of curvature configured to complement the implantation site radius of curvature.
A flexible osteochondral graft for implantation into an implant site having a radius of curvature said graft comprising:
- a cartilage layer and
- a boney region attached to the cartilage layer and having an outer surface wherein the graft has a harvested state with a first radius of curvature and an implantation state wherein an outer surface of the boney region is provided with a plurality of circular cuts that serve to decrease the radius of curvature of the outer surface from the first radius of curvature in the harvested state to a second radius of curvature configured to complement the radius of curvature of the implant site.
A flexible osteochondral graft for implantation into an implant site having a radius of curvature said graft comprising:
- a cartilage layer and
- a boney region attached to the cartilage layer and having an outer surface wherein the graft has a harvested state with a first radius of curvature and an implantation state wherein an outer surface of the boney region is provided with a plurality of linear cuts formed by waterjet cutting that serve to decrease the radius of curvature of the outer surface from the first radius of curvature in the harvested state to a second radius of curvature configured to complement the radius of curvature of the implant site, wherein the plurality of cuts includes
- a first set of cuts extending from the outer surface of the boney region to a predetermined depth and a second set of linear cuts within the boney region extending from a location between the surface on the predetermined depth of the first set of cuts and substantially through an opposing boney surface;
- wherein the cuts are between 0.01 mm and 1 mm in width;
- and wherein the cartilage layer has an average thickness of at least 0.5 mm.
Dependencies are inferred from the claim text.