Electronic apparatus for delivering coherent sine burst irreversible electroporation energy to a biological tissue

Electronic apparatus (100) for delivering Coherent Sine Burst Irreversible Electroporation energy to a biological tissue (1) to be treated, the electronic apparatus comprising:

• at least one electrode (3) positionable either on or near the biological tissue (1) to be treated;
• and
• a power generator (2) for supplying electric energy to the or each electrode (3), said power generator (2) being configured to generate a respective electric signal (S) to energize the or each individual electrode (3),
• wherein
• the or each electric signal (S) is formed by alternating over time a first electric signal (S1) with a second electric signal (S2), each first electric signal (S1) being the same;
• said first electric signal (S1) is supplied to an individual electrode (3) during a first time interval (T1) and said second electric signal (S2) is supplied to the individual electrode (3) during a second time interval (T2) subsequent to the first time interval (T1);
• said first electric signal (S1) is a continuous bipolar signal comprising two or more basic sine waves (SB) in said first time interval (T1), each basic sine wave having a peak-to-peak mean amplitude in the range 2,000 V to 20,000 V and consisting of one positive half-wave and one negative half-wave, each half-wave having the same width, and the first electric signal (S1) having a frequency in the range 25 kHz to 75 kHz;
• and
• said second electric signal (S2) has an amplitude equal to zero in said second time interval (T2).