Method for producing ketone derivative

A method for producing a ketone derivative (I) represented by the following formula (I):

• wherein W1 represents an alkyl group that may have a substituent, an alkenyl group that may have a substituent, a cycloalkyl group that may have a substituent, a heterocycloalkyl group that may have a substituent, an aryl group that may have a substituent, a heteroaryl group that may have a substituent, an arylalkyl group that may have a substituent or an arylalkenyl group that may have a substituent, and W2 represents an alkyl group that may have a substituent, an alkenyl group that may have a substituent, a cycloalkyl group that may have a substituent, a heterocycloalkyl group that may have a substituent, an aryl group that may have a substituent, an arylalkyl group that may have a substituent or an arylalkenyl group that may have a substituent,
• the method comprising mixing:
• a thioester derivative (II) represented by the following formula (II):
• wherein W1 is the same as defined above, and W3 represents an alkyl group that may have a substituent, an alkenyl group that may have a substituent, a cycloalkyl group that may have a substituent, a heterocycloalkyl group that may have a substituent, an arylalkyl group that may have a substituent or an arylalkenyl group that may have a substituent;
• a Grignard reagent (III) selected from the group consisting of
• a Grignard reagent (IIIa) represented by the following formula (IIIa):
• W2MgX (IIIa)
• wherein W2 is the same as defined above, and X represents a halogen atom, and
• a Grignard reagent (IIIb) represented by the following formula (IIIb):
• W2MgX·LiCl (IIIb)
• wherein W2 and X are the same as defined above;
• and
• a copper salt in a temperature range of 20° C. or more and 60° C. or less, to form the ketone derivative (I).