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US 2024/0018079 A1Published application
Method for purifying cannabinoid compounds
AssigneeChengdu Baiyu Pharmaceutical Co., Ltd
InventorsYi SUN, Xuezhen XU, Jing ZHANG, Yonggang WEI
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Abstract
Disclosed is a method for purifying cannabinoid compounds that enables cannabinoid compounds to be obtained more economically and with a better purification effect.
Claims10
A method for purifying cannabinoid compounds, stereoisomers, deuterated products or salts thereof, comprising:
- A-(OH)nA-(OG)nA-(OH)n
- wherein,
- A-(OH)n is:
- A-(OG)n is:
- wherein,
- is a single bond or a double bond;
- R0 is C1-6 alkyl or C1-6 hydroxyalkyl;
- R is H or C1-12 alkyl;
- R1 is H or —COOH;
- R2 is H, —COOH or C1-6 alkyl;
- R3 and R3′ are each independently OH or C1-6 alkoxy, and at least one of R3 and R3′ is C1-6 alkoxy;
- R4 is OH, C1-6 alkoxy, —COOH or —OCOC1-6 alkyl;
- G is a silyl protecting group;
- R3a and R3b are each independently —OG or C1-6 alkoxy, and at least one of R3a and R3b is —OG;
- n is 1 or 2.
12 more elements
A compound having the following structure:
- wherein:
- is a single bond or a double bond;
- R0 is C1-6 alkyl or C1-6 hydroxyalkyl;
- R is H or C1-12 alkyl;
- R1 is H or —COOH;
- R2 is H, —COOH or C1-6 alkyl;
- R3 and R3′ are each independently OH or C1-6 alkoxy, and at least one of R3 and R3′ is C1-6 alkoxy;
- R4 is OH, C1-6 alkoxy, —COOH or —OCOC1-6 alkyl;
- G is a silyl protecting group;
- R3a and R3b are each independently —OG or C1-6 alkoxy, and at least one of R3a and R3b is —OG;
- preferably, the C1-6 alkyl is methyl, the C1-6 hydroxyalkyl is —CH2OH, the C1-12 alkyl is pentyl, and the C1-6 alkoxy is —OCH3, the silyl protecting group is trimethylsilyl, triethylsilyl, triisopropylsilyl, tert-butyldimethylsilyl or tert-butyldiphenylsilyl.
8 more elements
Dependencies are inferred from the claim text.