Processes for the Preparation of Multicomponent Crystalline Forms of Active Pharmaceutical Ingredients Using Solvent Vapour

A process for the preparation of an existing crystalline solid form comprising an active pharmaceutical ingredient and a distinct pharmaceutically acceptable entity, the process comprising mixing, in the presence of solvent vapour, of:

• (i) the active pharmaceutical ingredient in solid form;
• and
• (ii) the pharmaceutically acceptable entity, in solid or liquid form,
• wherein the entity has a melting point greater than approximately 30° C. or a boiling point greater than approximately 150° C. and the pharmaceutically acceptable entity and active pharmaceutical ingredient are incorporated in the same crystalline lattice.