Systems and methods for rotational piercing of pre-filled medical delivery assemblies

A medical administration assembly, comprising:

• a collar defining a first end and a second end, the first end defining a mounting socket comprising an interior seat operable to accept an exterior flange of a blow-fill-seal (BFS) bottle that is axially mated and the second end defining a hub socket comprising internal threads;
• a needle hub comprising at least one external thread cooperatively mated with the internal threads of the collar to a first degree of advancement, the needle hub being coupled to a double-ended needle disposed through the needle hub, the double-ended needle comprising a multi-bevel piercing tip;
• and
• a cap covering an administration tip of the needle and the cap comprising an interior key that is operable to drive the needle hub to advance the at least one external thread of the needle hub to a second degree of advancement with respect to the internal threads of the hub socket of the collar,
• wherein advancement of the threads to the second degree of advancement causes the multi-bevel piercing tip of the double-ended needle to pierce a seal of the collar.

A multi-bevel cannula for a pre-filled medical delivery assembly, comprising:

• an elongate hollow tube body portion defining an interior fluid conduit and a first end and a second end thereof;
• the first end comprising a first bevel defining a first point for engagement with a patient;
• and
• the second end comprise a triple-bevel defining a second point for rotational piercing of a BFS vial.