Methods and compositions to increase lifespan and healthspan by mimicking the effects of time-restricted feeding
AssigneeThe Trustees of Columbia University in the City of New York
InventorsMimi Shirasu-Hiza, Julie Canman, Matt Ulgherait
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Abstract
The present disclosure relates to methods and compositions for increasing or extending lifespan and/or healthspan and/or delaying aging using agents which mimic the effects of time-restricted feeding and/or activate or enhance circadian-regulated autophagy. In particular, the present disclosure relates to increasing certain proteins including UNC-51-like kinase (ULK1), adenosine monophosphate protein kinase (AMPK) and microtubule-associated protein, light chain 3 (LC3), and decreasing other certain proteins including ribosomal protein S6 kinase beta-1 (S6K) protein in order to increase lifespan and/or healthspan and delay aging.
Claims19
1-17. (canceled)
A method of increasing and/or extending lifespan and/or healthspan and/or delaying aging in a subject by administering a therapeutically effective amount of an agent which activates or enhances circadian-regulated autophagy.
A method of preventing and/or treating an age-related illness in a subject by administering a therapeutically effective amount of an agent which activates or enhances circadian-regulated autophagy.
Dependencies are inferred from the claim text.