Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
AssigneeMedincell
InventorsGeorges GAUDRIAULT, Sylvestre GRIZOT, Mark HURTIG, Matthew SHIVE
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Abstract
A method of targeting to the synovial tissue biodegradable drug delivery compositions or morselizing biodegradable drug delivery compositions are described. The biodegradable drug composition comprises a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as at least one pharmaceutically active principle is disclosed.
Claims15
A biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer having the formula:
- PLAv-PEGw-PLAx
- wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x;
- (b) a biodegradable diblock copolymer having the formula:
- mPEGy-PLAz
- wherein y is the number of repeat units with y ranging from 3 to 45 and z ranging from 7 to 327, wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable diblock copolymer of (b) is 3:2 to 1:19 in said biodegradable drug composition;
- and
- (c) at least one pharmaceutically active principle which is delivered through morselization of said biodegradable drug delivery composition;
- wherein the PEG chain in at least one of the triblock and diblock copolymers is about 2 kDa.
A method for targeting at least one pharmaceutically active principle to at least one joint said method comprising administering to a mammal or animal in need of such treatment a biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer having the formula:
- PLAv-PEGw-PLAx
- wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x;
- (b) a biodegradable diblock copolymer having the formula:
- mPEGy-PLAz
- wherein y and z are the number of repeat units with y ranging from 3 to 45 and z ranging from 7 to 327, wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable diblock copolymer of (b) is 3:2 to 1:19 in said biodegradable drug composition;
- and
- (c) at least one pharmaceutically active principle.
Dependencies are inferred from the claim text.