Synchronization of ion generation with cycling of a discontinuous atmospheric interface
AssigneePurdue Research Foundation
InventorsRobert Graham Cooks, Guangtao Li, Guangming Huang, Jason Duncan, Xin Li, Ewa Sokol, Xin Yan
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Abstract
The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
Claims21
1-12. (canceled)
An online reaction monitoring system, the system comprising:
- a pressurized reaction vessel that comprises an outlet port;
- a channel that extends from within the outlet port;
- an electrode operably associated with a distal end of the channel;
- and
- a mass spectrometer, wherein the system is configured to operate without an pneumatic pump and pressure from the pressurized reaction vessel drives continuous flow from the pressurized reaction vessel, through the outlet port and channel and to the distal end of the channel.
An online reaction monitoring system, the system comprising:
- a reaction vessel that comprises an outlet port;
- a channel that extends from within the outlet port;
- an electrode operably associated with a distal end of the channel, wherein the electrode is inductively associated with the distal end of the channel and produces a positive electrical potential that is applied via the electrode that is not in physical contact with the channel or a solution in the channel and in a manner that produces electric fields of both polarities;
- and
- a mass spectrometer.
A method for monitoring a reaction in real-time, the method comprising:
- providing an online reaction monitoring system that comprises a reaction vessel that comprises an outlet port;
- a channel that extends from within the outlet port;
- an electrode operably associated with a distal end of the channel;
- and a mass spectrometer;
- selecting a solvent that is compatible as both a reaction solvent and an ionization solvent;
- conducting a reaction in the solvent in the reaction vessel;
- flowing a portion of the solvent from the reaction vessel through the channel;
- generating ions of one or more analytes in the solvent by applying an electrical potential to a distal end of the channel via the electrode;
- using the flowed portion of the solvent from the vessel as the ionization solvent;
- and
- analyzing the ions in the mass spectrometer, thereby monitoring the reaction in real-time.
Dependencies are inferred from the claim text.