Estimating hla expression loss

A system comprising:

• one or more data processors;
• and
• a non-transitory computer readable storage medium containing instructions which, when executed on the one or more data processors, cause the one or more data processors to:
• receive a set of exon-resolution identifiers for an allele pair associated with an MHC gene,
• wherein an exon-resolution identifier of the set of exon-resolution identifiers for a corresponding allele of the allele pair describes an allele group, a specific allele protein, and exon region information for the corresponding allele;
• identify, for each exon-resolution identifier of the set of exon-resolution identifiers, a set of intron-resolution identifiers to form a plurality of intron-resolution candidate identifiers,
• wherein an intron-resolution identifier of the set of intron-resolution identifiers for the corresponding allele describes the allele group, the specific allele protein, the exon region information, and intron region information for the corresponding allele;
• and
• generate a final set of intron-resolution identifiers for the allele pair from the plurality of intron-resolution candidate identifiers.

A computer-program product tangibly embodied in a non-transitory machine-readable storage medium, including instructions configured to cause one or more data processors to perform a method comprising:

• receiving a set of exon-resolution identifiers for an allele pair associated with an MHC gene,
• wherein an exon-resolution identifier of the set of exon-resolution identifiers for a corresponding allele of the allele pair describes an allele group, a specific allele protein, and exon region information for the corresponding allele;
• identifying, for each exon-resolution identifier of the set of exon-resolution identifiers, a set of intron-resolution identifiers to form a plurality of intron-resolution candidate identifiers,
• wherein an intron-resolution identifier of the set of intron-resolution identifiers for the corresponding allele describes the allele group, the specific allele protein, the exon region information, and intron region information for the corresponding allele;
• and
• generating a final set of intron-resolution identifiers for the allele pair from the plurality of intron-resolution candidate identifiers.