Systems and methods for whole-brain circuit-based neurostimulation totreat brain disorders
AssigneeNeurotherapeutix, LLC
InventorMarta Moreno
Life of this patent
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Abstract
Targeted and individualized methods are provided herein for determining specific treatment sites based on an individual patient. Embodiments described herein may use functional and/or structural connections to create brain mapping of the patient and/or control groups having the same metrics as the patient, and combinations thereof in determining target locations for stimulation treatment.
Claims21
1-25. (canceled)
A non-transitory computer-accessible medium having stored thereon computer-executable instructions for determining one or more target regions for transcranial magnetic stimulation (TMS) treatment of a patient, wherein the computer-executable instructions are configured when executed by one or more processors to perform a method, comprising:
- receiving functional magnetic resonance imaging (fMRI) data of a head of the patient;
- analyzing functional connections of the patient's brain through analysis of the fMRI data by determining changes in any combination of a first fluctuation in amplitude of the fMRI imaging data, a second fluctuation in frequency of the fMRI data, or a third fluctuation in frequency relative to amplitude of the fMRI data;
- and
- determining one or more target regions for TMS treatment of the patient based on the determination of any combination of the first fluctuation, the second fluctuation, or the third fluctuation.
A non-transitory computer-accessible medium having stored thereon computer-executable instructions for determining one or more target regions for transcranial magnetic stimulation (TMS) treatment of a patient, wherein the computer-executable instructions are configured when executed by one or more processors to perform a method, comprising:
- receiving fMRI data;
- construct covariation matrixes using the fMRI data;
- selecting a first set of potential targets with stronger covariation values with a first large group of brain regions, selecting a second set of potential targets with weaker covariation with a second large group of brain regions, or selecting a combination of the first set of potential targets and the second set of potential targets;
- receive dMRI data;
- use dMRI data to construct a structural connectivity matrix;
- select target regions from the first set of potential targets, the second set of potential targets, or the first and second set of potential targets with a higher number of white matter connections.
A non-transitory computer-accessible medium having stored thereon computer-executable instructions for determining one or more target regions for transcranial magnetic stimulation (TMS) treatment of a patient, wherein the computer-executable instructions are configured when executed by one or more processors to perform a method, comprising:
- receive dMRI data;
- use dMRI data to construct a structural connectivity matrix;
- select a set of potential targets with a lower number of white matter connections;
- receiving fMRI data;
- construct covariation matrixes using the fMRI data;
- selecting a first set of targets from the set of potential targets with stronger covariation values with a first large group of brain regions, selecting a second set of targets from the set of potential targets with weaker covariation with a second large group of brain regions, or selecting a combination of the first set of targets and the second set of targets.
Dependencies are inferred from the claim text.