Back to results
US 2023/0417754 A1Published application
Near infrared-ii probes as high affinity targeting imaging agents and uses thereof
AssigneeOn Target Laboratories, LLC
InventorSumith A. Kularatne
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods and compositions for detecting a target cell using a compound comprising a targeting moiety, a linker, and a NIR-II dye.
Claims32
A compound, or pharmaceutically acceptable salt of the compound, wherein the compound has the formula B-L-X,
- wherein B is a tumor targeted ligand which targets a folate receptor, Glutamate carboxypeptidase II, prostate-specific membrane antigen (PSMA), carbonic anhydrase IX (CA IX), Fibroblast activation protein alpha, Glucose transporter 1, or cholecystokinin,
- L is selected from the group consisting of a hydrophilic spacer, an amino acid, a peptidic or derivatives thereof, a polyether, a sulfonic acid or derivatives thereof, a glycans or derivatives thereof, and combinations thereof,
- and X is a NIR-II dye selected from the group consisting of:
3-6. (canceled)
8-13. (canceled)
(canceled)
24-30. (canceled)
(canceled)
(canceled)
(canceled)
41-43. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.