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US 2023/0417703 A1Published application
Software for microfluidic systems interfacing with mass spectrometry
AssigneeIntabio, Inc.
InventorsWei CHEN, Erik GENTALEN, Scott MACK, Alexander PETROV, Hongfeng YIN
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Abstract
Methods, devices, and systems for improving the quality of electrospray ionization mass spectrometer (ESI-MS) data are described, as are methods, devices, and systems for achieving improved correlation between chemical separation data and mass spectrometry data.
Claims21
A method comprising:
- loading a sample comprising at least one analyte of interest onto a fluidic device, wherein the fluidic devices comprises a fluid inlet, a fluid outlet, a separation channel, a first side channel and a second side channel;
- introducing the sample into the separation channel;
- introducing a catholyte into the fluidic device from the first side channel;
- separating the sample within the separation channel using isoelectric focusing, wherein said separation generates at least one focused analyte peak;
- introducing a mobilizer into the fluidic device from the second side channel;
- exposing the focused analyte to at least two different conductivity zones during mobilization via the first side channel and the second side channel;
- and
- expelling the focused and mobilized analytes via the fluid outlet into a mass spectrometer.
5 more elements
Dependencies are inferred from the claim text.