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US 2023/0416797 A1Published application
Modulating antimicrobial peptide half-life
AssigneeSyngulon SA
InventorPhilippe Gabant
Life of this patent
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Abstract
Methods of modulating the half-life of an antimicrobial peptide are described. The method may include administering an antimicrobial peptide to an environment where the antimicrobial peptide remains active until a specified endpoint, and on or after the specified endpoint, digesting the antimicrobial peptide with a protease to thereby inactivate the antimicrobial peptide and modulate its half-life. Compositions and kits for modulating the half-life of an antimicrobial peptide are also described.
Claims37
A method of modulating a half-life of an antimicrobial peptide, the method comprising:
- administering an antimicrobial peptide to an environment, wherein the antimicrobial peptide remains active in the environment until a specified endpoint;
- on or after the specified endpoint, digesting the antimicrobial peptide with a protease, thereby inactivating the antimicrobial peptide, thereby modulating the half-life of the antimicrobial peptide.
A composition comprising:
- a protease;
- an antimicrobial peptide comprising a cleavage site that is specifically digested by the protease;
- and
- a microbial organism capable of developing resistance to the antimicrobial peptide.
1 more element
A kit comprising:
- an antimicrobial peptide selected to target a microbial organism capable of developing resistance to the antimicrobial peptide;
- and
- a protease capable of digesting the antimicrobial peptide.
Dependencies are inferred from the claim text.