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US 2023/0416782 A1Published application
Enhanced nanoparticle delivery systems
AssigneeChildren's Hospital Medical Center
InventorsZiady G. Assem, Siefert Matthew
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for the enhancement of nucleic acid delivery systems. The methods may employ treatment with a compound and/or an RNAi molecule in combination with a nucleic acid to improve nucleic acid uptake into a cell. In particular, the disclosed methods may be useful for improved gene therapy techniques.
Claims18
A method for transferring a gene into a eukaryotic cell, comprising administering a compacted nucleic acid nanoparticle;
- and one or more active agent selected from sonolisib (Steroid Lactone), LY294002 (Benzopyran), TG100115 (Pteridine), Trifluoperazine (Benzothiazine, Phenothiazine), CEP5214 (Indole Derivative, Pyrrolocarbazole), Afuresertib (Substituted Benzene, Phenethylamine, Amphetamine), Cation Vemurafenib (Aryl-Phenylketone), Suramin (Benzene Derivative, Benzanilide), Uprosertib (Benzene Derivative, Phenethylamine, Amphetamine), Flutamide, (Benzene Derivative, Trifluoromethylbenzene), Enzastaurin (Indole Derivative, N-alkylindole), Fasudil (Isoquinoline derivative), Ruboxistaurin (Macrolactam), Pentamidine (Phenol Ether), Uprosertib (Benzene Derivative, Phenethylamine, Amphetamine), Lestaurtinib (Indole derivative, Indolocarbazole), Adenine (Imidazolepyrimidine), Pimozide (Diphenylbutylpiperidine), Chlorpromazine (Phenothiazine), Afuresertib (Benzene Derivative, Phenethylamine, Amphetamine), and combinations thereof, to a eukaryotic cell.
Dependencies are inferred from the claim text.