bZIP TRANSCRIPTION FACTORS REGULATE CONVERSION OF NICOTINE TO NORNICOTINE
AssigneesUniversity of Kentucky Research Foundation, R.J. Reynolds Tobacco Company
InventorsLing Yuan, Sanjay K. Singh, Sitakanta Pattanaik, Darlene Madeline Lawson
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Abstract
A method of decreasing conversion of nicotine to nornicotine is provided herein. The methods includes administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof. Also provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a bZIP type transcription factor binding site on a promoter of a nicotine N-demethylase (NND). Further provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a plant genome to knockout at least one bZIP type transcription factor.
Claims20
A method of decreasing conversion of nicotine to nornicotine, the method comprising administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof.
Dependencies are inferred from the claim text.