Sirna for treating hepatic fibrosis and delivery preparation thereof

A small interfering RNA that inhibits the expression of target gene NOX1, consisting of a sense strand and an antisense strand reversely complementary thereto, wherein sequences of the sense strand and the antisense strand are selected from the group consisting of:

• (1) sequences of No. 1 small interfering RNA
• the sense strand has a nucleotide sequence of 5′-GAGAUGUGGGAUGAUCGUGACTT-3′ (SEQ ID NO.1), and
• the antisense strand has a nucleotide sequence of 5′-GUCACGAUCAUCCCACAUCUCTT-3′ (SEQ ID NO.2);
• (2) sequences of No. 2 small interfering RNA
• the sense strand has a nucleotide sequence of 5′-CAAGCUGGUGGCCUAUAUGAUTT-3′ (SEQ ID NO.3), and
• the antisense strand has a nucleotide sequence of 5′-AUCAUAUAGGCCACCAGCUUGTT-3′ (SEQ ID NO.4);
• and
• (3) sequences of No. 3 small interfering RNA
• the sense strand has a nucleotide sequence of 5′-CUGAGUCUUGGAAGUGGAUCCUUTT-3′ (SEQ ID NO.5),
• the antisense strand has a nucleotide sequence of 5′-AAGGAUCCACUUCCAAGACUCAGTT-3′ (SEQ ID NO.6);
• wherein, the antisense strand is reversely complementary to a fragment of the target gene.