Materials and methods for treating corneal dysfunction
AssigneeUniversity of Miami
InventorsAlfonso L Sabater Gozalvo, Juan Pablo De Rivero Vaccari, Robert W. Keane, Enrique L. Salero-Coca
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Abstract
The present disclosure relates to materials and methods for treating or preventing corneal dysfunction or ocular surface disease.
Claims25
A method of treating or preventing corneal dysfunction in a mammalian subject in need thereof, the method comprising administering to the subject an inflammasome inhibitor in an amount effective to treat or prevent the corneal dysfunction.
A method of treating or preventing ocular surface disease in a mammalian subject in need thereof, the method comprising administering to the subject an inflammasome inhibitor in an amount effective to treat or prevent the ocular surface disease or damage.
A method of diagnosing ocular surface damage in a mammalian subject in need thereof, the method comprising:
- determining a level of caspase-1 in a tear sample from the subject, wherein an elevated level of caspase-1 in the sample compared to a level of caspase-1 control sample identifies the subject as likely to be suffering from ocular surface damage.
Dependencies are inferred from the claim text.