Compositions and methods for inhibiting mapt expression
AssigneeDicerna Phrmaceuticals, Inc.
InventorsBob Dale BROWN, Henryk T. DUDEK, Seongmoon CHEONG, Shiyu WANG, Travis GRIM, Matthew Guese COSTALES, Maire JUNG
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Abstract
Oligonucleotides are provided herein that inhibit MAPT gene expression, including oligonucleotides conjugated to a targeting ligand (e.g., lipid moiety). Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders, and/or conditions associated with MAPT gene expression.
Claims44
An RNAi oligonucleotide for reducing MAPT gene expression, the oligonucleotide comprising a sense strand and an antisense strand, wherein the sense strand is 15 to 50 nucleotides in length, wherein the sense strand and the antisense strand form a duplex region, wherein the antisense strand comprises a region of complementarity to a MAPT mRNA target sequence of any one of SEQ ID NOs:
- 912-1295, and wherein the region of complementarity is at least 15 contiguous nucleotides in length.
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Dependencies are inferred from the claim text.