Compositions targeting pacs1 and methods of use thereof
AssigneeBoard of Regents, The University of Texas System
InventorsBruce Beutler, Evan D. Nair-Gill
Life of this patent
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Abstract
Compositions and methods for attenuating or preventing lymphoproliferation in a subject are provided. The subject may have, be suspected of having, or at risk of having a lymphoproliferative disease. The methods herein include administering to the subject a composition effective for decreasing phosphofurin acidic cluster sorting protein 1 (Pacs1) expression and/or activity.
Claims27
A method for attenuating or preventing lymphoproliferation in a subject in need thereof, the method comprising administering to the subject a composition effective for modulating phosphofurin acidic cluster sorting protein 1 (Pacs1),
- wherein modulating Pacs1 comprises decreasing Pacs1 gene expression, decreasing Pacs1 protein expression, decreasing Pacs1 activity, or any combination thereof.
A composition comprising at least one inhibitor of phosphofurin acidic cluster sorting protein 1 (Pacs1), and a pharmaceutically acceptable carrier.
A kit comprising a composition effective for modulating phosphofurin acidic cluster sorting protein 1 (Pacs1), and at least one container,
- wherein modulating Pacs1 comprises decreasing Pacs1 gene expression, decreasing Pacs1 protein expression, decreasing Pacs1 activity, or any combination thereof.
Dependencies are inferred from the claim text.