Mucin 5b (muc5b) irna compositions and methods of use thereof

A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of Mucin 5B (MUC5B) in a cell,

• (a) wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region,
• wherein the sense strand comprises a nucleotide sequence comprising at least 15 contiguous nucleotides, with 0, 1, 2, or 3 mismatches, of a portion of the nucleotide sequence of SEQ ID NO:1, or a nucleotide sequence having at least 90% nucleotide sequence identity to a portion of the nucleotide sequence of SEQ ID NO:1, and the antisense strand comprises a nucleotide sequence comprising at least 15 contiguous nucleotides, with 0, 1, 2, or 3 mismatches, of the corresponding portion of the nucleotide sequence of SEQ ID NO:6, or a nucleotide sequence having at least 90% nucleotide sequence identity to a portion of the nucleotide sequence of SEQ ID NO:6;
• and
• wherein the sense strand or the antisense strand is conjugated to one or more lipophilic moieties;
• or
• (b) wherein the antisense strand comprises a region complementary to part of an mRNA encoding a MUC5B gene (SEQ ID NO:1), wherein each strand independently is 14 to 30 nucleotides in length;
• and wherein the sense strand or the antisense strand is conjugated to one or more lipophilic moieties;
• or
• (c) wherein the antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the antisense nucleotide sequences in any one of Tables 2-7, 9, and 10, wherein each strand independently is 14 to 30 nucleotides in length;
• and wherein the sense strand or the antisense strand is conjugated to one or more lipophilic moieties.