Dipeptidylpeptidase and leucine aminopeptidase polypeptide variants
AssigneeAmyra Biotech A G
InventorsWerner TSCHOLLAR, Silvia TIETZ
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to polypeptides with peptidase activity that are truncated variants of dipeptidylpeptidase IV (DPPIV) and leucine aminopeptidase (LAP) polypeptides, nucleic acids such as vectors encoding them, as well as host cells comprising the nucleic acids described herein and optionally expressing the polypeptides described herein. The polypeptides and nucleic acids described herein are useful in medical applications such as in the treatment of gluten-related disorders including celiac disease (CeD) and non-celiac gluten sensitivity (NCGS) as well as other diseases that may profit from a gluten-free diet (GFD).
Claims32
A polypeptide comprising a truncated dipeptidylpeptidase IV (DPPIV) polypeptide.
A polypeptide selected from the group consisting of:
- (i) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 1-748 of SEQ ID NO:
- 1;
- (ii) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 1-747 of SEQ ID NO:
- 1;
- (iii) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 1-746 of SEQ ID NO:
- 1;
- (iv) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 1-745 of SEQ ID NO:
- 1;
- (v) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 2-748 of SEQ ID NO:
- 1;
- (vi) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 2-747 of SEQ ID NO:
- 1
- (vii) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 2-746 of SEQ ID NO:
- 1;
- and
- (viii) a polypeptide comprising a truncated DPPIV polypeptide consisting of an amino acid sequence represented by residues 2-745 of SEQ ID NO:
- 1.
A polypeptide comprising a truncated leucine aminopeptidase (LAP) polypeptide.
A polypeptide selected from the group consisting of:
- (i) a polypeptide comprising a truncated LAP polypeptide consisting of an amino acid sequence represented by residues 7-471 of SEQ ID NO:
- 2;
- (ii) a polypeptide comprising a truncated LAP polypeptide consisting of an amino acid sequence represented by residues 7-463 of SEQ ID NO:
- 2;
- (iii) a polypeptide comprising a truncated LAP polypeptide consisting of an amino acid sequence represented by residues 7-458 of SEQ ID NO:
- 2;
- (iv) a polypeptide comprising a truncated LAP polypeptide consisting of an amino acid sequence represented by residues 7-457 of SEQ ID NO:
- 2;
- and
- (v) a polypeptide comprising a truncated LAP polypeptide consisting of an amino acid sequence represented by residues 7-456 of SEQ ID NO:
- 2.
(canceled)
Dependencies are inferred from the claim text.