Use of therapeutic enzyme fusion protein in prevention and treatment of neuropathy caused by or accompanied by fabry disease
AssigneeHanmi Pharm. Co., Ltd.
InventorsJin Young KIM, Cho Rong PARK, Sang Yun KIM, Won Ki KIM, Su Yeon PARK
Life of this patent
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Abstract
A use of a fusion protein of a therapeutic enzyme and an immunoglobulin Fe region is disclosed. The fusion protein is represented by the following chemical formula 1. The fusion protein shows protective effects on peripheral sensory nerves and exhibits an extended duration in the body. Thus, the fusion protein or a composition containing the fusion protein can be used in the prevention or improvement of neuropathy.
Claims15
A method for preventing or treating neuropathy caused by or accompanied by Fabry disease, comprising administering a pharmaceutical composition to a patient in need thereof, wherein the pharmaceutical composition comprises an enzyme fusion protein represented by the following Chemical Formula 1:
- wherein X and X′ are each alpha-galactosidase;
- L and L′ are linkers, each independently the same or a different kind of linker;
- F is one polypeptide chain of an immunoglobulin Fc region;
- | is a covalent bond;
- and
- :
- is a covalent or non-covalent bond.
Dependencies are inferred from the claim text.