Modified bacteriophage
OwnerHeather FAIRHEAD, Adam WILKINSONinventors
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Abstract
A modified bacteriophage capable of infecting a plurality of different target bacteria, which bacteriophage includes a toxin gene encoding a toxin protein which is toxic to the target bacteria; wherein the bacteriophage is lytic; and wherein the bacteriophage expresses host range determinant proteins which have a plurality of bacterial host specificities.
Claims21
A modified bacteriophage capable of infecting a plurality of different target bacteria, which bacteriophage includes a toxin gene encoding a toxin protein which is toxic to the target bacteria;
- wherein the bacteriophage is lytic;
- and wherein the bacteriophage expresses host range determinant proteins which have a plurality of bacterial host specificities.
2-45. (canceled)
A modified bacteriophage capable of infecting a plurality of different target bacteria, which bacteriophage comprises a variant of bacteriophage Phi33 which has been modified to comprise an α/β small acid-soluble spore protein (SASP) gene encoding a SASP gene which is expressed under the control of a constitutive promoter, and further wherein the bacteriophage is lytic.
Dependencies are inferred from the claim text.