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US 2023/0416692 A1Published application
Reverse genetic system for sars-cov-2
AssigneeBoard of Regents, The University of Texas System
InventorsPEI-YONG SHI, VINEET MENACHARY, Xuping Xie
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Abstract
Certain embodiments of the invention include recombinant reverse genetic systems for SARS-COV-2 virus.
Claims19
A recombinant DNA expression cassette comprising a SARS-CoV-2 nucleic acid segment that is at least 95% identical to the nucleic acid sequence of SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3.
A recombinant cDNA comprising a nucleotide sequence that is at least 95% identical to SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3.
An assay for SARS-CoV-2 replication comprising:
- contacting a cultured cell expressing or containing a nucleotide sequence at least 95% identical to SEQ ID NO:3 forming a test cell;
- contacting the test cell with a agent;
- and
- assessing the replication of SARS-CoV-2 in the presence of the test agent.
1 more element
Dependencies are inferred from the claim text.