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AssigneeS & E Bio Corporation
InventorsEun Hee Kim, Eun Kyoung Shin, Ji Hee Sung
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The present invention relates to: a method in which extracellular vesicles with improved therapeutic efficacy are produced from a three-dimensional spheroid-type cell aggregate produced using a microwell having a particular structure; and extracellular vesicles produced by the production method. When the method for producing extracellular vesicles, according to the present invention, is used, extracellular vesicles having enhanced efficacy can be mass-produced, and the produced extracellular vesicles include higher levels of various efficiency factors than existing extracellular vesicles and exhibit uniform characteristics without difference between donors, and thus can be used for various purposes in the medical industry.
A method for producing extracellular vesicles derived from a three-dimensional spheroid-type cell aggregate comprising:
A composition for producing extracellular vesicles comprising a three-dimensional spheroid-type cell aggregate produced by 3 dimensionally (3D)-culturing mesenchymal stem cells in a microwell with a diameter of 200 to 800 μm and a depth of 100 to 1000 μm.
A method for reducing a donor variation of extracellular vesicles derived from a cell aggregate comprising:
A method for producing extracellular vesicles derived from a cell aggregate with a reduced donor variation comprising:
Dependencies are inferred from the claim text.