Polyrotaxane having hydroxy group or sulfo group
AssigneesDenka Company Limited, National University Corporation Tokyo Medical and Dental University
InventorsRuriko AOYAMA SEKIYA, Yoshinori ARISAKA, Nobuhiko YUI, Takanori IWATA, Tetsuya YODA, Masahiro HAKARIYA, Hiroki MASUDA
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Abstract
A coating agent for promoting osteoblast differentiation and/or adipocyte differentiation of mesenchymal stem cells, the coating agent comprising a polyrotaxane represented by Formula (1): wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500, is a cyclodextrin in which at least one hydroxyl group is modified with a group represented by —X—Y, X is a divalent organic group, and Y is a hydroxyl group or a sulfo group.
Claims15
A coating composition for promoting osteoblast differentiation or adipocyte differentiation of mesenchymal stem cells, the coating composition comprising:
- a polyrotaxane represented by Formula (1):
- wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500,
- is a cyclodextrin in which at least one hydroxyl group is modified with a group represented by —X—Y, X is a divalent organic group, and Y is a hydroxyl group or a sulfo group.
A cell culture method for promoting osteoblast differentiation or adipocyte differentiation of mesenchymal stem cells, the method comprising:
- culturing mesenchymal stem cells on a surface of a substrate coated with a composition comprising a polyrotaxane represented by Formula (1):
- wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500,
- is a cyclodextrin in which at least one hydroxyl group is modified with a group represented by —X—Y, X is a divalent organic group, and Y is a hydroxyl group or a sulfo group.
A culture substrate comprising a substrate coated with a composition comprising a polyrotaxane represented by Formula (1):
- wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500,
- is a cyclodextrin in which at least one hydroxyl group is modified with a group represented by —X—Y, X is a divalent organic group, and Y is a hydroxyl group or a sulfo group.
Dependencies are inferred from the claim text.