Method for operating bioprocessing system and bioprocessing system
AssigneeAlfa Laval Corporate AB
InventorsStaffan KÖNIGSSON, Peter THORWID
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Abstract
A method for operating a bioprocessing system includes producing a cell culture mixture in a fermentor, conducting a flow of cell culture mixture from the fermentor into an interior of a centrifugal separator including a surface enlarging insert, simultaneously with the step of producing the cell culture mixture, and returning continuously from the interior of the centrifugal separator a flow of liquid to the fermentor, simultaneously with the steps of producing the cell culture mixture and conducting the flow of cell culture mixture.
Claims23
A method for operating a bioprocessing system, comprising the steps of:
- producing a cell culture mixture in a fermentor;
- conducting a flow of cell culture mixture from the fermentor into an interior of a centrifugal separator comprising a surface enlarging insert, simultaneously with the step of producing the cell culture mixture;
- and
- returning continuously from the interior of the centrifugal separator a flow of liquid to the fermentor, simultaneously with the steps of producing the cell culture mixture and conducting the flow of cell culture mixture.
18-23. (canceled)
A bioprocessing system comprising a fermentor for producing therein a cell culture mixture, a centrifugal separator comprising a surface enlarging insert, a receiving container, a conduit system interconnecting the fermentor, the centrifugal separator, and the receiving container, flow control equipment arranged in the conduit system, and a control system configured for controlling the centrifugal separator and at least part of the flow control equipment,
- wherein the control system is configured to:
- conduct a flow of cell culture mixture from the fermentor into an interior of the centrifugal separator, and simultaneously;
- and
- continuously return from the interior of the centrifugal separator a flow of liquid to the fermentor.
26-45. (canceled)
(canceled)
Dependencies are inferred from the claim text.