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US 2023/0416489 A1Published application
Polymer compositions
AssigneeOxford Medical Products Limited
InventorsAnthony John FITZPATRICK, Xue MIN, Jan Tadeusz CZERNUSZKA
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AssigneeOxford Medical Products Limited
InventorsAnthony John FITZPATRICK, Xue MIN, Jan Tadeusz CZERNUSZKA
Estimating the term…
The invention relates to novel a high-volume swelling hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, and/or a semi-interpenetrating network and/or simple cross-linked arrangement of a plurality of one or more species of hydrophilic polymers, optionally together with one or more biocompatible polymers and optionally together with one or more plasticising agents, characterised in that at least some of the pores are at least partially collapsed and/or flattened, and further characterised in that the interpenetrating network and/or semi-interpenetrating network and/or cross-linked arrangement which defines the collapsed and/or flattened pores is substantially unbroken. The invention also relates to a process for preparing such hydrogels, and to their use as an appetite suppressant.
A dosage regimen comprising the step of administering to a patient, suffering from one or more medical conditions selected from obesity and diabetes, a first dose of a product formulation, which is retained in the stomach of the treated patient for at least one day, the first dose comprising one or more compressed hydrogels in an amount which will swell to fill up to 80% of the volume of the treated patient's stomach.
An orally acceptable product formulation comprising a plurality of discrete core and shell regions such that the one or more core regions are surrounded by the one or more shell regions, wherein the one or more shell regions comprise a first component and the one or more core regions comprise a second component;
Dependencies are inferred from the claim text.