Carbohydrate crosslinker
AssigneeGalderma Holding SA
InventorsHotan MOJARRADI, Johan OLSSON, Craig Steven HARRIS, Jean-Guy BOITEAU, Thibaut GERFAUD, Loïc TOMAS
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Abstract
The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.
Claims20
A hyaluronic acid (HA) hydrogel comprising HA molecules crosslinked by diaminotrehalose (DATH), wherein the hydrogel is prepared by a process comprising:
- hydrolyzing ester bonds in the crosslinked HA molecules via alkaline hydrolysis to obtain a hydrogel having less than 50% non-crosslinked HA molecules by weight of the hydrogel.
The HA hydrogel according to claim 2, wherein the HA molecules are crosslinked by the DATH via activated carboxyl groups on the HA molecules.
Dependencies are inferred from the claim text.