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US 2023/0416413 A1Published application
Therapeutic use of mitochondria and combined mitochondrial agents
AssigneesChildren's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
InventorsJames D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
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Abstract
The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
Claims28
A method of transplanting a mass of cells or tissues from a first subject to a second subject, the method comprising:
- contacting the mass of cells or tissues with an effective amount of a composition comprising exogeneous mitochondria such that the exogenous mitochondria are incorporated within the mass of cells or tissues to generate a modified mass of cells or tissues comprising the exogenous mitochondria;
- and
- transplanting the modified mass of cells or tissues into the second subject.
A method of transplanting a cell into a subject, the method comprising:
- contacting the cell with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the cell to generate a modified cell comprising the exogenous mitochondria;
- and transplanting the cell to the subject.
A method of transplanting an organ into a subject, the method comprising:
- contacting the organ with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the organ to generate a modified organ comprising the exogenous mitochondria;
- and transplanting the organ to the subject.
Dependencies are inferred from the claim text.