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US 2023/0416409 A1Published application
Anti-ceramide antibodies
AssigneesMemorial Sloan Kettering Cancer Center, Ceramide Therapeutics
InventorsJimmy ROTOLO, Richard KOLESNICK
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Abstract
Monoclonal antibodies directed to ceramide that inhibit apoptosis are disclosed. Humanized and scFv versions of the antibodies are also disclosed. Methods for prevention or treatment of apoptosis in a subject by administration of the anti-ceramide antibodies are disclosed.
Claims1
A method of inhibiting apoptosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-ceramide antibody or antigen-binding fragment comprising a variable heavy chain (VH) and a variable light chain (VL), wherein
- the VH comprises a heavy chain variable region CDR1 comprising the sequence GYTFTDHTIH (SEQ ID NO:
- 1), a heavy chain variable region CDR2 comprising the sequence YNYPRDGSTKYNEKFKG (SEQ ID NO:
- 2), and a heavy chain variable region CDR3 comprising the sequence GFITTVVPSAY (SEQ ID NO:
- 3), and
- the VL comprises a light chain variable region CDR1 comprising the sequence RASKSISKYLA (SEQ ID NO:
- 4), a light chain variable region CDR2 comprising the sequence SGSTLQS (SEQ ID NO:
- 5), and a light chain variable region CDR3 comprising the sequence QQHNEYPWT (SEQ ID NO:
- 6).
5 more elements
Dependencies are inferred from the claim text.