Human antibodies against tissue factor and methods of use thereof

A human antibody which binds human Tissue Factor, wherein the antibody comprises:

• (a) a VH region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:14, 15 and 16 and a VL region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:70, 71 and 72,
• (b) a VH region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:18, 19, 20 and a VL region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:74, 75 and 76,
• (c) a VH region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:22, 23 and 24 and a VL region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:78, 79 and 80,
• (d) a VH region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:
• 26, 27 and 28 and a VL region comprising the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:
• 82, 83 and 84, or
• (e) a variant of any of (a)-(d), wherein said variant has at most 1, 2 or 3 amino-acid modifications.