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US 2023/0416392 A1Published application
Anti-cd20 antibody and uses thereof
AssigneeMemorial Sloan Kettering Cancer Center
InventorsIsabelle Riviere, Ouathek Ouerfelli, Xiuyan Wang, Frances Weis-Garcia
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Abstract
Provided herein are anti-CD20 antibodies and uses thereof for treatment and diagnosis. Also provided are CD20 antigens for the production of anti-CD20 antibodies and methods of generating anti-CD20 antibodies using the CD20 antigens.
Claims15
A method of treatment comprising
- a. isolating T-cells from a subject,
- b. transfecting the T-cells with a vector comprising a nucleic acid encoding an isolated antibody or an antigen binding portion thereof that specifically binds to a canine CD20 cyclic peptide having the sequence of SEQ ID NO:
- 20, wherein the cysteine at position 7 of SEQ ID NO:
- 20 forms a disulfide bond with the cysteine at position 23 of SEQ ID NO:
- 20, and
- c. administering the transfected T-cells to the subject.
3 more elements
Dependencies are inferred from the claim text.