Multivalent and Multispecific 41BB-Binding Proteins
AssigneeInhibrx, Inc.
InventorsBrendan P. Eckelman, John C. Timmer, Chelsie Macedo, Kyle S. Jones, Abrahim Hussain, Amir S. Razai, Bryan Becklund, Rajay Pandit, Mike Kaplan, Lucas Rascon, Quinn Deveraux
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Abstract
This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfamily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB.
Claims18
-47. (canceled)
An isolated polypeptide comprising at least one VHH domain that binds 41BB, and at least one VHH domain that binds OX40, DR5 or GITR, wherein each VHH domain that binds 41BB comprises a CDR1, a CDR2, and a CDR3, respectively, comprising the amino acid sequences of SEQ ID NOs:
- 26, 27 and 28;
- or SEQ ID NOs:
- 26, 61, and 28;
- or SEQ ID NOs:
- 26, 63, and 28;
- or SEQ ID NOs:
- 26, 71, and 28;
- or SEQ ID NOs:
- 26, 73, and 28;
- or SEQ ID NOs:
- 26, 75, and 28;
- or SEQ ID NOs:
- 26, 77, and 28;
- or SEQ ID NOs:
- 26, 79, and 28;
- or SEQ ID NOs:
- 65, 61, and 28;
- or SEQ ID NOs:
- 67, 61, and 28;
- or SEQ ID NOs:
- 69, 61, and 28.
The method of claim 65, wherein the cancer is selected from carcinoma, sarcoma, lymphoma, and leukemia.
Dependencies are inferred from the claim text.