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US 2023/0416371 A1Published application
Heterodimer fc polypeptide
OwnerHitoshi KATADA, Kanako TATSUMIinventors
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Abstract
In one non-limiting embodiment, polypeptides comprising a variant Fc region which contains amino acid alterations in a parent Fc region, and methods for producing such polypeptides, are provided.
Claims31
A polypeptide which comprises a variant Fc region composed of two polypeptide chains, and wherein the variant Fc region comprises amino acid alterations at the following positions:
- (i) positions 234, 235, 236, 239, 268, 270, and 298 according to EU numbering in the first polypeptide chain;
- and
- (ii) positions 270, 298, 326, and 334 according to EU numbering in the second polypeptide chain.
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A polypeptide which comprises a variant Fc region composed of two polypeptide chains, and wherein the variant Fc region comprises amino acid alterations at the following positions:
- (i) positions 234, 235, 236, 239, 268, 270, 298, 330, and 332 according to EU numbering in the first polypeptide chain;
- and
- (ii) positions 236, 270, 298, 326, 330, 332, and 334 according to EU numbering in the second polypeptide chain.
(canceled)
(canceled)
Dependencies are inferred from the claim text.