Anti-cd22 nano antibody and use thereof

A nanobody or an antigen-binding fragment that specifically binds to CD22, wherein the nanobody or the antigen-binding fragment comprises a combination of CDRs, the combination of CDRs comprises:

• CDR1, CDR2, and CDR3;
• the CDR1, CDR2 and CDR3 have any sequence combination selected from the following, or a sequence combination with 1, 2, 3 or more amino acid insertions, deletions and/or substitutions compared to the sequence combination:
• SEQ ID NO.
• No.
• CDR1
• CDR2
• CDR3
• VH1
• SEQ ID NO. 57
• SEQ ID NO. 58
• SEQ ID NO. 59
• VH2
• SEQ ID NO. 60
• SEQ ID NO. 61
• SEQ ID NO. 62
• VH3
• SEQ ID NO. 63
• SEQ ID NO. 64
• SEQ ID NO. 65
• VH4
• SEQ ID NO. 66
• SEQ ID NO. 67
• SEQ ID NO. 68
• VH5
• SEQ ID NO. 69
• SEQ ID NO. 70
• SEQ ID NO. 71
• VH6
• SEQ ID NO. 72
• SEQ ID NO. 73
• SEQ ID NO. 74
• VH7
• SEQ ID NO. 75
• SEQ ID NO. 76
• SEQ ID NO. 77
• VH8
• SEQ ID NO. 78
• SEQ ID NO. 79
• SEQ ID NO. 80
• VH9
• SEQ ID NO. 81
• SEQ ID NO. 82
• SEQ ID NO. 83
• VH10
• SEQ ID NO. 84
• SEQ ID NO. 85
• SEQ ID NO. 86
• VH11
• SEQ ID NO. 87
• SEQ ID NO. 88
• SEQ ID NO. 89
• VH12
• SEQ ID NO. 90
• SEQ ID NO. 91
• SEQ ID NO. 92
• VH13
• SEQ ID NO. 93
• SEQ ID NO. 94
• SEQ ID NO. 95
• VH14
• SEQ ID NO. 96
• SEQ ID NO. 97
• SEQ ID NO. 98
• VH15
• SEQ ID NO. 99
• SEQ ID NO. 100
• SEQ ID NO. 101
• VH16
• SEQ ID NO. 102
• SEQ ID NO. 103
• SEQ ID NO. 104
• VH17
• SEQ ID NO. 105
• SEQ ID NO. 106
• SEQ ID NO. 107
• VH18
• SEQ ID NO. 108
• SEQ ID NO. 109
• SEQ ID NO. 110
• VH19
• SEQ ID NO. 111
• SEQ ID NO. 112
• SEQ ID NO. 113
• VH20
• SEQ ID NO. 114
• SEQ ID NO. 115
• SEQ ID NO. 116
• VH21
• SEQ ID NO. 117
• SEQ ID NO. 118
• SEQ ID NO. 119
• VH22
• SEQ ID NO. 120
• SEQ ID NO. 121
• SEQ ID NO. 122
• VH23
• SEQ ID NO. 123
• SEQ ID NO. 124
• SEQ ID NO. 125
• VH24
• SEQ ID NO. 126
• SEQ ID NO. 127
• SEQ ID NO. 128
• VH25
• SEQ ID NO. 129
• SEQ ID NO. 130
• SEQ ID NO. 131
• VH26
• SEQ ID NO. 132
• SEQ ID NO. 133
• SEQ ID NO. 134
• VH27
• SEQ ID NO. 135
• SEQ ID NO. 136
• SEQ ID NO. 137
• VH28
• SEQ ID NO. 138
• SEQ ID NO. 139
• SEQ ID NO. 140
• VH29
• SEQ ID NO. 141
• SEQ ID NO. 142
• SEQ ID NO. 143
• VH30
• SEQ ID NO. 144
• SEQ ID NO. 145
• SEQ ID NO. 146
• VH31
• SEQ ID NO. 147
• SEQ ID NO. 148
• SEQ ID NO. 149
• VH32
• SEQ ID NO. 150
• SEQ ID NO. 151
• SEQ ID NO. 152
• VH33
• SEQ ID NO. 153
• SEQ ID NO. 154
• SEQ ID NO. 155
• VH34
• SEQ ID NO. 156
• SEQ ID NO. 157
• SEQ ID NO. 158
• VH35
• SEQ ID NO. 159
• SEQ ID NO. 160
• SEQ ID NO. 161
• VH36
• SEQ ID NO. 162
• SEQ ID NO. 163
• SEQ ID NO. 164
• VH37
• SEQ ID NO. 165
• SEQ ID NO. 166
• SEQ ID NO. 167
• VH38
• SEQ ID NO. 168
• SEQ ID NO. 169
• SEQ ID NO. 170
• VH39
• SEQ ID NO. 171
• SEQ ID NO. 172
• SEQ ID NO. 173
• VH40
• SEQ ID NO. 174
• SEQ ID NO. 175
• SEQ ID NO. 176
• VH41
• SEQ ID NO. 177
• SEQ ID NO. 178
• SEQ ID NO. 179
• VH42
• SEQ ID NO. 180
• SEQ ID NO. 181
• SEQ ID NO. 182
• VH43
• SEQ ID NO. 183
• SEQ ID NO. 184
• SEQ ID NO. 185
• VH44
• SEQ ID NO. 186
• SEQ ID NO. 187
• SEQ ID NO. 188
• VH45
• SEQ ID NO. 189
• SEQ ID NO. 190
• SEQ ID NO. 191
• VH46
• SEQ ID NO. 192
• SEQ ID NO. 193
• SEQ ID NO. 194
• VH47
• SEQ ID NO. 195
• SEQ ID NO. 196
• SEQ ID NO. 197
• VH48
• SEQ ID NO. 198
• SEQ ID NO. 199
• SEQ ID NO. 200
• VH49
• SEQ ID NO. 201
• SEQ ID NO. 202
• SEQ ID NO. 203
• VH50
• SEQ ID NO. 204
• SEQ ID NO. 205
• SEQ ID NO. 206
• VH51
• SEQ ID NO. 207
• SEQ ID NO. 208
• SEQ ID NO. 209
• VH52
• SEQ ID NO. 210
• SEQ ID NO. 211
• SEQ ID NO. 212
• VH53
• SEQ ID NO. 213
• SEQ ID NO. 214
• SEQ ID NO. 215
• VH54
• SEQ ID NO. 216
• SEQ ID NO. 217
• SEQ ID NO. 218
• each CDR1, CDR2 and CDR3 is coded according to the prevailing analysis methods of KABAT, Chothia or IMGT;
• preferably, the substitution is a conservative amino acid substitution.